Indications:
● Colds
● Hayfever
● Sneezing
● Coughing
● Itchy
● Watery red eyes
● Runny or blocked nose
Pharmacology:
Pharmacokinetics:
Pharmacokinetics of Diphenhydramine Hydrochloride:
Absorption: Quickly absorbed with maximum activity occurring in approximately one hour.
Protein Binding: 98 to 99%
Metabolism: Hepatic and renal
Route of Elimination: Little, if any, is excreted unchanged in the urine; most appears as the degradation products of metabolic transformation in the liver, which are almost completely excreted within 24 hours.
Half Life: 1-4 hours.
Rationale of Combination:
Diphenhydramine is an antihistamine that relieves congestion and post-nasal drips, while ammonium chloride is the expectorant which thins mucus. Sodium citrate is a mucolytic, an agent which breaks down mucus, so that coughing up phlegm is easier and Menthol helps clear. LICENSED INDICATION.
Drug Interactions:
● Alcohol, drugs for anxiety and sleeping tablets if co-administered along with the medication lead to enhanced sedation.
● Monoamine oxidase inhibitors and tricyclic antidepressants increase the occurrence of Diphenhydramine relating side-effects.
Disease Interactions: Consult your doctor before using this drug if you have asthma, liver or kidney disease, glaucoma, epilepsy, a heart rhythm disturbance, an enlarged prostate, difficulty urinating, or if you have been diagnosed with myasthenia gravis.
Side Effects:
● Dry mouth
● Dizziness
● Headache
● Nausea/Vomitting
● Gastrointestinal discomfort.
Contraindications:
● Contraindicated in patients with a known hypersensitivity towards any ingredient of the product.
Pregnancy:Avoid: Potential risk to the foetus has been reported. Consult your doctor before use, or if you are planning to fall pregnant.
Breastfeeding:Avoid: It is unknown how this medication may affect your baby. Consult your doctor before use.
Porphyria:Avoid: It is unknown how this medication may affect your condition. Consult your doctor before use. Infants and children: this medication is not intended for use in children under the age of 6 years.
Precautions:
The Elderly: Caution is advised in the elderly as adverse effects may be more likely.
Driving and Hazardous work: This medication should be avoided as it may cause extreme sedation.
Alcohol: Avoid concomitant use of alcohol with this medication.
Over Dosage:
A small overdose is no cause for concern. In case of intentional large overdose, seek emergency medical attention.