Indications and Usage
● Enlarged prostate
● In prostate Hyperplasia
● Reduces the risk of urinary retention
Pharmacology
Mechanism of Action:
Dutasteride prevents the conversion of the testosterone to dihydrosterone by inhibiting the enzyme 5-alpha reductase , as dihydrotesterone causes enlargement of the prostate gland.
Pharmacokinetics:
Absorption: It is orally absorbed.
Protein Binding: It is about 99.9% bound to serum albumin and 96.8% bound to alpha-1 acid glycoprotein
Metabolism: It is metabolized in the liver to 4, 5 hydroxydutasteride.
Excretion: Excreted via kidney.
Side Effects
● Impotence
● Tenderness in breast and increase in breast size
● Swelling and pain in the testicles
Contraindication
● Contraindicated in patients with renal impairment
● Contraindicated in patients with known hypersensitivity
● Contraindicated in pregnant women
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