Mechanism
Ferrous bisglycinate: It consists of one molecule of ferrous iron bound to two molecules of glycine. Ferrous bisglycinate enjoys the privilege of being a highly absorbable iron supplement exceeding ferrous salts
Low dose of ferrous bisglycinate, may be equivalent to a higher dose of ferrous salt with regard to hematological and iron status when used by expectant women. This finding is important for the prevention of iron deficiency and iron deficiency anemia that often coincides with pregnancy.
Iron is critical to human life. It plays the central role in the hemoglobin molecule of our red blood cells (RBCs), where it functions in transporting oxygen from the lungs to the body's tissues. It also functions in several key enzymes in energy production and metabolism, including DNA synthesis.
The main features of Ferrous Bisglycinate are:
- A non-constipating, well-absorbed form of iron
- An essential mineral for red blood cell formation
- Absorbed intact
- Easily absorbed into the mucosal tissue
- Highest bioabsorption
- High bioavailability even in presence of phytates, tannates, oxalates etc.
- Less likely to cause intestinal side effects such as nausea, constipation and bloating
- Does not interact with multivitamins
Manganese:It is an essential trace mineral that is required in small amounts to manufacture enzymes necessary for the metabolism of proteins and fats. It also supports the immune system and blood-sugar balance and is involved in the production of cellular energy, reproduction, and bone growth.
Manganese works with vitamin K to support normal blood clotting. Working with the B-complex vitamins, manganese helps promote a positive outlook when faced with stress, frustration, and anxiety.
Iron and manganese work closely together, and a strong inverse relationship between deficiency in iron and high manganese levels has been found. While overly high manganese can contribute to anemia, manganese also helps the body use and store iron to some degree as well, which can help prevent anemia (low iron).
It is essential for proper iron metabolism and so helps prevent anemia.
Riboflavin (vitamin B2)It is manufactured in the body by the intestinal flora and is easily absorbed, although very small quantities are stored, so there is a constant need for this vitamin.
It is required by the body to use oxygen and in the metabolism of amino acids, fatty acids, and carbohydrates. Riboflavin is further needed to activate vitamin B6 (pyridoxine), helps to create niacin and assists the adrenal gland. It may be used for red blood cell formation, antibody production, cell respiration, and growth.
Vitamin B2 is responsible for maintaining healthy blood cells, helping to boost energy levels, facilitating in a healthy metabolism, preventing free radical damage, contributing to growth, protecting skin and eye health, and even more.
It is used for red blood cell formation, antibody production, cell respiration, and growth.
CopperCopper is a mineral and also needed in relatively small amounts. Copper is required in the formation of hemoglobin, red blood cells as well as bones, while it helps with the formation of elastin as well as collagen - making it necessary for wound healing.
It is needed to absorb and utilize iron. The influence of copper upon health is due to the fact that it is part of enzymes, which are proteins that help biochemical reactions occur in all cells. Copper is involved in the absorption, storage, and metabolism of iron. The symptoms of a copper deficiency are similar to iron-deficiency anemia. Copper may be absorbed by both the stomach and small-intestinal mucosa, with most absorbed by the small intestine. Copper is found in the blood bound to proteins.
It is required in the formation of hemoglobin, red blood cells as well as bones.
Folic acid It is a B vitamin that is an essential requirement of the body. It is needed for making the genetic material of cells (DNA), and thus for growth and development. Folic acid is particularly important for the maintenance of a healthy nervous system and in the formation of red blood cells, which carry oxygen around the body.
Folic acid is most important for rapidly growing tissues, such as those of a fetus, and rapidly regenerating cells, like red blood cells and immune cells. Folic acid deficiency results in an anemia that responds quickly to folic acid supplements.
The need for folic acid increases considerably during pregnancy. Deficiencies of folic acid during pregnancy are associated with low birth weight and an increased incidence of neural tube defects in infants.
It is important for healthy cell division and replication also required for protein metabolism and in treating anemia.
Vitamin B12:It is commonly known as Cyanocobalamin. Vitamin B12 is the "generic descriptor" name for any of such vitamers of vitamin B12. Because the body can convert cyanocobalamin to any one of the active vitamin B12 compounds, by definition this makes cyanocobalamin itself a form (or vitamer) of B12.
Vitamin B12 helps in the production of healthy red blood cells that carry oxygen around the body.
It works with folate to make nucleic acids. Part of its structure is cobalt and it needs intrinsic factor in order to work. Part of coenzymes for blood formation and required for nerve functioning and for homocysteine breakdown.
Also, a vitamin B12 benefit is its ability to help in healthy regulation of the nervous system, including reducing such mood disorders as depression and anxiety.
It is required for the formation blood and for the normal functioning of brain and nervous system.
Pharmacokinetics
- Absorption: Ferrous bisglycinate absorbed efficiently in intestine.
- Distribution: Iron stored in liver, bone marrow, and spleen.
- Metabolism: Vitamins metabolized in liver.
- Elimination: Iron via feces; vitamins via urine.
- Half-life: Varies by component.
Side Effects
- Mild gastric upset
- Constipation
- Nausea
- Rare: hypersensitivity reactions
Contraindication
- Hemochromatosis
- Wilson’s disease
- Hypersensitivity to any component
Interaction
- Antacids: May reduce iron absorption.
- Tetracyclines: Reduced absorption with iron.
- Alcohol: Chronic use may impair vitamin metabolism.
Warning and Precautions
- Monitor hemoglobin and ferritin levels during therapy.
- Use cautiously in patients with liver disorders.
- Store in a cool, dry place.
Dosage
As directed by the Dietician.
