Indications:
●Allergic Rhinitis: Levocitrizine Dihydrochloride is indicated for the relief of symptoms associated with allergic rhinitis (seasonal and perennial) in adults and children 6 years of age and older.
●Chronic Idiopathic Urticaria: Levocitrizine is indicated for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria in adults and children 6 years of age and older.
Pharmacology:
Pharmacokinetics:
Absorption: Rapidly and extensively absorbed. T max is 0.9 h. C max is 270 and 308 ng/mL after single and repeated once-daily dosing, respectively. Steady state achieved after 2 days.
Distribution: Plasma protein binding about 92%. Vd is approximately 0.4 L/kg.
Metabolism: Metabolism is less than 14% and by aromatic oxidation, N- and Odealkylation, and taurine conjugation.
Elimination: The t ½ is about 8 to 9 h. Elimination is 85.4% and 12.9% via urine and feces, respectively. Excreted both by glomerular filtration and active tubular transport.
Mode of Action:
The active component of Levocetirizine dihydrochloride, is the R enantiomer of cetirizine hydrochloride, a racemic compound with antihistaminic properties. It is an orally active and selective H1-receptor antagonist. Histamines act on H1 receptors, causing the symptoms commonly seen in allergic reactions. Its inhibits these H1 receptors.
Drug Interactions:
Like cetirizine, levocetirizine is to a high degree excreted unchanged: less than 14% of a given dose is converted into metabolites. There are several different metabolic pathways, including through the CYP1A2, 2C9, 2C19, 2D6, 2E1 and 3A4t pathways in the liver. A total of 13 different metabolites have been observed. In vitro studies have shown that levocetirizine does not affect the CYP isoenzymes of the liver, and the risk of interactions in connection with metabolism is considered to be very low.
There is a risk of interaction if the drug is used concurrently with alcohol or other CNS depressants.
Adverse Effects:
The most commonly reported adverse effects are:
● Sleepiness
● Dizziness
● Dry Mouth
Driving and Using Machineries:
"This medication is not applicable since they are intended for use in children from 6months to 12 years of age."
"However, this information is relevant to the active Ingredients, Levocetirizine dihydrochloride."
"Caution when driving or operating machinery."
"Response to medication may vary from one individual to another, contain side effects like (vertigo, dizzies nervousness, insomnia) that have been reported very rarely with the medicine may affect some patient's ability to drive, operate machinery."
Storage:
Store in a well closed container in cool, dry place, away from direct heat and light.
Conclusion:
From the above discussion, it can be concluded that this Levocetirizine dihydrochloride suspension could improve the quality of life of children with Allergic Rhinitis and Chronic Idiopathic Urticaria.
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