Our composition contains Methylcobalamin which is better absorbed and retained than other forms of B12 (such as cyanocobalamin). Methylcobalamin protects nerve tissue and brain cells and promotes better sleep. Methylcobalamin is a cofactor of methionine synthase, which reduces toxic homocysteine to the essential amino acid methionine. Methylcobalamin also protects eye function against toxicity caused by excess glutamate.
L-Methylfolate is involved in neurotransmitter synthesis and critical enzyme reactions throughout the body. By depleting excess homocysteine folate benefits cardiovascular health and nervous system function.
Pyridoxal -5-phosphate plays a role in the synthesis of nucleic acids RNA and DNA, aids in the maintenance of the sodium-potassium balance, promotes red cell formation and provides nutritional support to the nervous system.

Indication:
● Useful in diabetic neuropathy
● Effective in peripheral neuropathy
● Effective in the treatment of vitamin B12 deficiency
● Useful in anemia
● Beneficial in depression
● Helps to regulate blood sugar (glucose) levels
● Helps the immune system to produce antibodies which are needed to fight off diseases
● Effective in skin disorders
● Maintenance of the sodium-potassium balance
● Promotes new cells formation and growth

Pharmacology:

Mechanism of Action:
This combination provides nutritional requirements needed to restore metabolic processes associated with diabetic neuropathy to maintain blood flow by increasing nitric oxide resulting in vasodilation.
L-Methylfolate Primary biologically active isomer of folic acid and the primary form of folate in circulation; folic acid is a precursor of tetrahydrofolic acid, which is involved as a cofactor for transformylation reactions.
Pyridoxal 5′-phosphate (PLP): Active form of vitamin B6
Methylcobalamin One of 2 forms of biologically active vitamin B12
Absorption:
Peak plasma time: 1.3 hr
Peak plasma concentration: 129 ng/mL
AUC: 383 mcg•h/mL
Distribution:
Protein bound: 56%
Vd: Wide distribution, RBC levels of folate remain elevated for periods in excess of 40 days following discontinuation of supplementation
Elimination:
Half-life: 3 hr
Excretion: Primarily in urine

Adverse Reactions:
● Allergic reactions
● Acne
● Skin reactions
● Allergic reactions
● Photosensitivity
● Nausea
● Vomiting