Infertility can negatively impact health, quality of life and psychological wellbeing. Among fertility disorders, polycystic ovary syndrome is one of the most common problems in women. PCOS is the main cause of infertility due to metabolic, hormonal and ovarian dysfunctions. Women affected by PCOS often suffer of insulin resistance and of a compensatory hyperinsulinemia. These conditions put the patients at risk of developing several metabolic disorders.
PCOS" is short for "polycystic ovary syndrome" or polycystic ovarian syndrome". The most common is "polycystic ovaries", which means an excessive number of underdeveloped follicles on your ovaries. The most distressing aspects of PCOS are inability to ovulate and become pregnant, weight gain, hair loss, unwanted facial and body hair growth, and acne.
Poor nutrition often plays a major role, as does exposure to certain chemicals. Age plays less of a role before menopause. Many women turn to a low-fat, high fiber diet in an attempt to increase health and lose weight. Weight loss has been shown to increase fertility, but losing weight in this way is rarely effective for increasing fertility because it deprives the body of the necessary proteins and fats necessary for hormone production.
Many factors influence your chances of conception, including age, general health and stress levels, as well as sperm and egg quality. The more you are in balance in mind, body and spirit, the greater your chance of conception and the healthier your baby is likely to be. However, inadequate diet, intensive food production and processing and the demands of job, travel and family, can mean that our nutritional needs are not meeting adequately.
There are many other lifestyle factors that contribute as well:
- Lack of sleep
- Exposure to harmful chemicals
- Lack of exercise (or too much exercise)
- High stress levels
- Certain medications or supplements
Myo Inositol plays a key role in follicular development, improves oocyte (egg) quality and helps in the restoration of ovulation in women
NAC improves menstrual cyclicity
Folic acid is helpful in regulating homocysteine levels, promoting ovarian and smooth functioning and improves PCOS symptoms
Vitamin E improves glucose metabolism and insulin activity for PCOS and diabetes
L-Carnitine improves pregnancy rates and ovulation induction in clomiphene resistant PCOS
L-Arginine helpful for PCOS as they can improve your insulin sensitivity and also can have an effect on weight loss
Selenium improves insulin sensitivity and lipids in women with PCOS
So, the rational use of nutritional supplements, combined with a healthy diet, will contribute substantially to health promotion and work in balance and synergism on protection and integration of the physiological functions of the body.
Indications & Usage:
This formula is useful in:
- PCOS (Polycystic ovary syndrome)
- Improves egg quality and pregnancy rate in women with failed IVF (In Vitro Fertilization)
- Improves pregnancy rate and lower cancellation rate in women with PCOS
- Restores normal ovulatory activity and fertility in women with PCOS
- Oligomenorrohea and Amenorrhoea
- Induces menses and increases chances of ovulation
- Increased SHBG (sex hormone binding globulin) – Deals with any free testosterone in our blood stream
- Loweres testosterone levels
- Improves insulin sensitivity
- Decreases luteinizing hormone
- Improves appetite balance
Myo-Inositol: D-myo-Inositol is an insulin-sensitizing supplement that is useful in polycystic ovarian syndrome and other insulin resistant fertility concerns. Inositol has shown favorable results in improving nearly all aspects of PCOS, including insulin sensitivity, reproduction (restores ovulation and improves oocyte quality), hormonal imbalance, (improves androgens) and metabolic issues (inflammation, dyslipidemia, hypertension, and weight loss). Insulin resistance and/or compensatory hyperinsulinemia have a central role in the pathogenesis of PCOS. Inositol-phosphogycan (IPG) is a mediator of insulin action. Inositol also serves as a precursor for the synthesis of phosphoinositides, which constitute the phosphatidylinositol signal transduction system involved in the regulation of various cellular functions including cell proliferation. Inositol, along with estradiol in human follicular fluid, also plays a role in follicular maturity and provides a marker of good quality oocytes. Research also shows that inositol is a simple and safe treatment that is capable of improving reproductive axis functioning in PCOS patients, reducing the hyperinsulinemic state that affects LH secretion and restoring spontaneous ovarian activity and consequently clinical pregnancy rate.
The main functions are:
- Inositol improves ovarian activity, insulin sensitivity and fertility in patients with PCOS
- Inositol also decreases testosterone and is a marker of good egg quality
N-Acetyl Cysteine: Nutritional supplement N-Acetyl Cysteine, also known as NAC. NAC is both an antioxidant and amino acid (building blocks of protein). Specifically, NAC is a derivative of the amino acid L-cysteine, an essential precursor used by the body to produce glutathione. Glutathione is an antioxidant that protects against free radical damage and oxidative stress and is a critical factor in supporting a healthy immune system. NAC has been shown to improve menstrual regularity and may help improve insulin resistance in women with PCOS who have high insulin levels. NAC also seems to have a favorable effect of lowering cholesterol, triglycerides and testosterone.
The main functions are:
- Breaks down mucus in the body
- Helpful in polycystic ovary syndrome in women
- Increases ovulation rates for women suffering from PCOS
- Raises cellular glutathione levels
- Improves length of egg's telomeres, maintaining egg quality and health
- Improves insulin resistance by reducing insulin levels and increasing insulin sensitivity
- Improves menstrual cyclicity, ovulation and pregnancy
Vitamin E: Vitamin E is a well – known antioxidant and protects cell membrane from oxidative damage. Vitamin E is generally safe and potent supplement that ameliorates problems associated with PCOS, diabetes and heart disease. Women at high risk for stroke or bleeding problems should be aware that high amounts of Vitamin E can worsen their problems. Women with PCOS have a higher risk of developing diabetes. Diabetics suffer damage to blood vessels, especially in the eyes and kidneys. Long-term use of vitamin E has been shown to strengthen major blood vessels in diabetics. Vitamin E also improves insulin action in non-insulin-dependent diabetics. Vitamin E helps with diabetes, hair loss, infertility, insulin resistance & irregular or absent periods. It is a powerful antioxidant that plays a protective role in the body as well as boosting your immune system, balancing blood sugar, improving hair and skin conditions.
Vitamin E may also play a role in reducing the risk of heart disease (important for women with PCOS).Oxidative stress is a major concern for women who are trying to conceive and have either insulin resistant, PCOS or diabetes. Vitamin E supplementation has been shown to improve insulin action. Vitamin E supplementation reduces oxidative stress, improving cell membrane physical characteristics and related activities in the transport of glucose.
L-Carnitine: L-Carnitine is an amino acid which plays an important role in energy metabolism in three different ways: the metabolism of glucose, the production of energy from stored fats and as an antioxidant, protecting cells from oxidative damage as a result of metabolism.
L-Carnitine is used in the PCOS to increase insulin sensitivity which is key to reversing insulin resistance, considered to be the main underlying cause of PCOS. The main function of L-carnitine is to help the body turn fat into energy.
Carnitine is a "vitamin-like" molecule that helps to transport long-chain fatty acids from outside the mitochondria (the energy powerhouse of the cell) to inside the mitochondria, a process that is vital to energy production.
L-carnitine improves pregnancy rates and ovulation and helps in lowering down the concentrations of sex hormone binding globulin (SHBG); thereby helping the symptoms of hirsutism and menstrual irregularities.
L-Arginine: L – Arginine is a semi essential amino acid, which means that although the body normally makes enough of it, supplementation with additional amounts is sometimes needed. Arginine is found in foods containing protein. Arginine with N-acetyl cysteine (NAC) restored gonadal function in patients with PCOS. N-acetyl cysteine and L-arginine are known to increase ovarian activity and improves insulin function. N-acetyl Cysteine helps in decreasing the oxidative stress and inhibiting the release of excess insulin and testosterone.
It increases blood flow which can improve reproductive health and allows for better blood circulation to the ovaries, allowing for optimum egg production. The increased blood flow to the uterus also creates a better environment to allow the implantation of a fertilized egg. Blood flow is important for the proper functioning of the reproductive organs, and may improve the chances of conception.
Folic Acid: Folic acid is also known as Vitamin B9 and it is required for DNA synthesis and optimal neurological function. It works in tandem with vitamin B12. Folic acid may be helpful in reducing homocysteine, which is a metabolic byproduct that is too high in some PCOS women.
Folic acid may help treat ovulatory infertility - one of the major complications of PCOS. PCOS has been associated with high blood levels of a substance called homocysteine. Elevated homocysteine levels have been linked to heart disease, stroke and endocrine disorders like hyperinsulinemia. Besides possibly reducing infertility associated with PCOS, folic acid may also improve pregnancy outcomes with PCOS. As with all pregnant women, pregnant women with PCOS need to get sufficient folic acid to prevent neural tube defects. Both low folic acid levels and PCOS are linked to miscarriage; pregnant women with PCOS may thus help reduce their risk of miscarrying by taking folic acid.
Selenium: Selenium is a mineral required in small amounts to maintain good health. It is necessary to generate antioxidant proteins that help prevent cell damage from free radicals, which are thought to contribute to the development of certain chronic diseases. Selenium also has a role in regulating thyroid gland function and the immune system.
Selenium supplementation could be effective on reproductive outcomes, biomarkers of inflammation, and oxidative stress among women with polycystic ovary syndrome (PCOS). It performs a variety of vital functions. It is an important antioxidant and a co-factor in thyroid function. In women who have an autoimmune disease of the thyroid (Hashimoto's disease), selenium appears to reduce the severity of the disorder.
Antioxidant element selenium has protective effects on oxidative stress and cytosolic Ca(2+) concentrations in human neutrophil. The importance of Ca(2+) influx into the neutrophils through TRPV1 channels in the pathogenesis of the patients with PCOS. The selenium appeared to provide a protective effect against oxidative stress and Ca (2+) entry through modulation of neutrophil TRPV1 calcium channel. Selenium may play a role in the pathogenesis of PCOS related with hyperandrogenism.
Low selenium is associated with diabetes and metabolic syndrome, both of which have some similarities with PCOS.
Side Effects :
The product is possible safe for most women. There is no disadvantage associated with the product if taken under the recommended usage or as directed by dietician.
Special Precautions & Warnings(For Pregnancy and Breast - Feeding mothers):
Store in a cool, dry & dark place. Protected from direct sunlight.