This is synergistic combination of the nutritional adjuvant - helps in diabetic mellitus. These nutrients can sometimes provide extra nutritional benefit to people with special health problems, including diabetes Diabetes mellitus is the physical ailment that sets in once the body starts building up a resistance to the insulin generated by the pancreas. This results in the sugars flooding the bloodstream as they cannot be absorbed into the tissues of the body. Diabetes is also accompanied by excessive thirst and micturition, in most cases. This results in the depletion of the body’s reserves of essential nutrients and minerals. Vitamins and minerals play an important role in glucose metabolism, so these nutrients deficiencies and the potential utility of supplementation is relevant to the management of type 2 diabetes mellitus (DM). These supplements can regulate metabolism and influence the development and progression of Diabetes. Eventually, we may be able to tailor nutritional recommendations to individuals’ unique genetic makeup, thus increasing the potential benefit and positive outcomes of medical nutrition therapy. Supplements – vitamins and minerals that our bodies require in small quantities for specific functions. They most commonly function as essential coenzymes and cofactors for metabolic reactions and thus help support basic cellular reactions (i.e., glycolysis, the citric acid cycle, lipid and amino acid metabolism) required to maintain energy production and life. Even moderate deficiencies can lead to serious disease states.

Indications
  • Effective in numerous neurodegenerative problems
  • Improves nerve conduction velocity
  • Beneficial effects in diabetic neuropathy
  • Useful as anti-stress strategy
  • Improves nerve function
  • Beneficial for atypical depression
  • Dietary supplement during pregnancy and lactation

About Composition
Several vitamins and supplements have been shown to play some positive role in helping Diabetic Peripheral Neuropathy (DPN). These nutrients and supplements that have shown some supportive role toward:
  • Healthy blood sugar levels - the foundation of nerve health.
  • Healthy nerves to alleviate direct nerve damage and its symptoms.
  • Healthy blood circulation to the nerves to indirectly support relief of diabetic neuropathy

Nicotinamide:
Niacin (vitamin B3) occurs in two forms: nicotinic acid and nicotinamide. The active coenzyme forms (nicotinamide adenine dinucleotide [NAD] and NAD phosphate) are essential for the function of hundreds of enzymes and normal carbohydrate, lipid, and protein metabolism. It can be used for people with high cholesterol.

Zinc:
The presence of a zinc deficiency in the body has also been suggested to contribute to the development of diabetes in some humans. Zinc itself may be a crucial element in insulin metabolism. Zinc is well-known as a powerful guardian against viral infections, and may also act to protect beta cells from destruction. Type 1 diabetics are often zinc deficient, and supplements have been shown to lower blood sugar levels in some type 1 cases. Zinc is vital among the minerals for diabetes control as it ensures that insulin is aptly released into the bloodstream. Diabetic persons should include zinc in their diet.

Pyridoxine HCl:
Pyridoxine supplements may be able to improve glucose tolerance, particularly for sufferers from gestational diabetes, or impaired glucose tolerance. Neuropathy, the severe damage caused to the nervous system by high blood sugar levels, may be associated with deficiency of pyridoxine. This supplement acts as an essential cofactor for hundreds of enzymes and plays a role in glucose, lipid, and amino acid metabolism and neurotransmitter synthesis. The active coenzyme form of the vitamin, pyridoxal-5-phosphate, in muscle tissue is closely associated with glycogen phosphorylase. Vitamin B6 also has a strong role to play in diabetes-related complications.

Folic Acid:
Folic acid is the synthetic form of the vitamin - Folate, yet another B vitamin (B9), is also essential to many of body’s functions. Folate is an essential coenzyme for reactions involving the transfer of one-carbon-units in amino acid and nucleic acid synthesis. The human body needs Folic acid to make, repair, and regulate DNA, to develop red blood cells, to support good nervous system function, and to act as a cofactor in many of the biological reactions that keep you healthy. Folic acid participates in the breakdown of fat in fat cells and may have some role in the prevention of obesity and type-2 diabetes. Many people know that diabetes is a disease of blood sugar control, but many do not know that it is also a disease of fat storage. Any dietary nutrient that plays a supportive role in proper fat metabolism needs to be a regular part of the diabetes and pre-diabetes diet.

Selenium:
Selenium, a trace mineral and antioxidant which plays a crucial role in human health, is a basic component of selenoprotein, an important enzyme in the body. Selenium play a functional role in redox homeostasis, thyroid hormone metabolism, and protection from oxidative stress and inflammation. Oxidative stress reduces insulin secretion and increases insulin resistance in some experimental models and may thus play a causal role in the pathogenesis of diabetes. Selenium, an essential trace element, is involved in the complex system of defense against oxidative stress through selenium-dependent glutathione peroxidases and other selenoproteins. Because of its antioxidant properties, selenium might thus prevent the development of diabetes and has been reported to have strong antidiabetic and insulin-mimetic effects.

Chromium:
Chromium is an essential trace mineral that plays a role in the metabolism of glucose and in supporting healthy blood sugar levels in people with diabetes. It benefits nerve health in diabetes and pre-diabetes through this well-known ability to support healthy blood sugar levels. Chromium positively supports healthy blood sugar levels and support insulin sensitivity, and healthy blood sugar levels in some diabetics. Optimal levels may reduce insulin resistance, improve blood sugar control, and may help to reduce the risk of cardiovascular disease and type-2 diabetes. Supplementation may also help to reduce triglycerides and total cholesterol while improving HDL "good" cholesterol. Chromium may enhance the effects of insulin or support the activity of pancreatic cells that produce insulin. Chromium’s actions have been attributed to an increase in the number of insulin receptors, increased binding of insulin to the insulin receptor, and increased activation of the insulin receptor in the presence of insulin.

Cyanocobalamin:
Vitamin B12 may have a strong role to play when treating diabetic neuropathy. The presence of vitamin B12 is necessary for the correct functioning of nerve cells and therefore taking it as a supplement may help to reduce nerve damage. Vitamin B12's main functions are in the formation of red blood cells and DNA that make up your genes. It is involved in having a healthy nervous system, and plays a vital role in the metabolism of healthy fats essential for maintenance of the important covering that surrounds your nerves known as the myelin sheath. In the diabetic, B12 is typically used to assist in the management of diabetic neuropathy, and for general nerve health. Vitamin B12 that has been studied for DPN is its role in managing homocysteine levels - Elevated levels of homocysteine in the blood have been associated with poor circulation, and it is believed that the decreased circulation in the tiny blood vessels that feed the nerves are part of the problem in people with DPN.

Vitamin B complex forms part of coenzymes essential for the metabolism of proteins, carbohydrates and fatty acids:
Trace elements are required for various metabolic processes.
Chromium, Zinc and Selenium (CZS) are trace elements essential for normal biochemical processes. In diabetes mellitus type I and type II lack or absence of insulin is the fundamental defect. The CZS elements are integral to normal insulin action.


WARNING: However, most people with diabetes will still have to take traditional prescription medicine to keep their blood sugar levels in control.

Side Effects
The product is possible safe for most adults. There is no disadvantage associated with the product if taken under the recommended usage.

Contraindications
Hypersensitivity to any ingredient of the composition

Special Precautions & Warnings

(For Pregnancy and Breast – Feeding mothers):
  • Pregnant and lactating mothers should not take any single supplement in higher – than – normal doses unless recommended by a health – care provider for special conditions.
  • The combination should only be used in pregnancy and lactation if benefits outweigh the risk.

Storage
Store in a cool, dry & dark place. Protected from direct sunlight and heat.