Hydrochlorothiazide is a diuretic, which is commonly referred to as a "water pill." It works by increasing the amount of salt and water that the kidneys remove from the blood. This extra salt and water are passed out through the urine. By increasing the amount of water removed from the blood, hydrochlorothiazide causes a decrease in blood volume.
Indications and Usage:
High Blood Pressure (Hypertension)
Drug Interaction:
● Complementry mechanism of action
● Reduction in peripheral resistence with ARB
● Reduction of fluid volume with Diuretics
● ARBs counteract reactive increase in blood pressure related to diuretic induced renin secretion
● ARBs ameliorates diuretic induced potassium depletion
● Well tolerated; fewer metabolic disturbances
● No significant variation in pharmacokinetic parameters of telmisartan in presence of hydrochlorothiazide
Combination of telmisartan with hydrochlorothiazide was found to be more effective than each agent alone in lowering blood pressure. Indeed , combining telmisartan with hydrochlorothiazide enhances the antihypertensive efficacy of telmisartan in patients not adequately controlled with telmisartan alone.
Pharmacokinetic:
Telmisartan is orally well absorbed and metabolized to an active metabolite which is more potent than Losartan as AT1 antagonist. Orally administered hydrochlorothiazide is rapidly absorbed and diuretic effect is seen in 1 hour and their duration lasts up to 12-24 hours. Both telmisartan and hydrochlorothiazide has longer duration of actions. These agents are bound to plasma proteins to varying degrees and this has no correlation to their half-life.
Pharmacodynamics:
The pharmacodynamics of telmisartan & hydrochlorothiazide has been investigated in vitro and in vivo in rodents, guinea pigs, rabbits and dogs. The combination of telmisartan with hydrochlorothiazide (40 mg/12.5 mg and 80 mg/12.5 mg) is expected to benefit patients with hypertension who are not adequately responsive to telmisartan alone.
Contraindications:
● Second and third trimesters of pregnancy.
● Biliary obstructive disorders.
● Severe hepatic impairment.
Conclusion:
This is a new combination for a muscle relaxant and displays anti - inflammatory and analgesic properties. Thiocolchicoside & Diclofenac Sodium is well absorbed from the gastrointestinal tract. It shows its effect in 1 - 2 hr after oral administration. This combination is used to treat various painful inflammatory conditions. Diclofenac Sodium has an outstanding anti-inflammatory profile mediated primarily through inhibition of cyclooxygenase (COX) activity and suppression of PGE2 synthesis From the above discussion, it can be concluded that this medicine could improve the quality of life of patients with as well as muscle relaxant in addition. Moreover it has a considerable safety profile, with persistent results.
Storage:
This medicinal product does not require any special temperature storage conditions. Store in the original package in order to protect from moisture.