Aceclofenac belongs to the group of anti-inflammatory drugs used for the treatment of inflammatory and painful such as low back pain, toothache and joint pain, osteoarthritis and rheumatoid arthritis.
Rabeprazole Sodium is an antiulcer drug in the class of proton pump inhibitors. Proton pump inhibitors act by irreversibly blocking the hydrogen/potassium adenosine triphosphatase enzyme system (the H+/K+ ATPase, or more commonly, the gastric proton pump) of the gastric parietal cells. The proton pump is the terminal stage in gastric acid secretion, being directly responsible for secreting H+ ions into the gastric lumen, making it an ideal target for inhibiting acid secretion.
Indication and Usage:
● Treatment of duodenal ulcers
● Gastroesophageal reflux disease (GERD)
● Maintaining healing and reducing relapse rates of heartburn symptoms in patients with GERD
● Peptic ulcer disease (PUD)
● Treatment of pathological hypersecretory conditions (Zollinger-Ellison syndrome)
Mechanism of Action: Combination of Aceclofenac and Rabeprazole is very effective against mild to moderate pain and ulcers. Like other NSAIDS, it has anti-inflammatory and analgesic activity and work by inhibiting the action of synthesis through the inhibition of both COX-1 and COX-2. This leads to the reduction of inflammation, pain, fever, and swelling, which are mediated by prostaglandins.
Rabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H+, K+ATPase at the secretory surface of the gastric parietal cell. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, rabeprazole has been characterized as a gastric proton-pump inhibitor. Rabeprazole blocks the final step of gastric acid secretion.
Drug Interactions: BEFORE TAKING THIS TELL THE DOCTOR ABOUT ANY MEDICAL PROBLEMS AN ALLERGIES THAT PATIENT HAS NOW OR HAS HAD.
Usually drug interactions occur when it is taken with another drug or with food. Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications. Aceclofenac and Rabeprazole may increase plasma concentrations of lithium, digoxin and methotrexate, increase the activity of anticoagulant, inhibits the activity of diuretics, enhance cyclosporin nephrotoxicity and precipitate convulsions when co-administered with quinolone antibiotics. And also decreases the concentration of ketoconazole in the plasma (in 33%), increases the concentration of digoxin (in 22%), and does not interact with liquid antacids.
Adverse Effects:
Headache, abdominal pain, dry mouth, dizziness, nausea and diarrhea.
Conclusion:
We are manufacturing Combination of Aceclofenac and rabeprazole which is superior form other NSAIDs as it has selectivity for cox-2, a beneficial cox inhibitor, well tolerated, better GI tolerability and improved cardiovascular safety when compared to other selective cox-2 inhibitors with combination of rabeprazole it work as gastric proton-pump inhibitor. It also work against Gastroesophageal reflux disease by blocking the final step of gastric acid secretion by inhibiting the gastric H+, K+ATPase at the secretory surface of the gastric parietal cell.
We are making superior quality of Aceclofenac and rabeprazole capsules that is used to treat Mild to moderate pain and Gastroesophageal reflux disease. Our offered capsules is processed using high grade chemical compounds by our experienced quality controllers that ensure its quality, purity and chemical properties. Highly treasured among the clients for its reliability, accurate composition, excellent physical and purity, this capsules is offered to our esteemed clients at the market leading prices.