Before knowing its combination, first we should need to know that how they work individually, so we know that ondansetron hydrochloride is antiemetic agent and used to treat nausea, vomiting, dyspepsia, peptic ulcer disease and gastroesophageal reflux disease. ondansetron hydrochloride work by competitively block the action of serotonin at 5HT3 receptors peripherally in the gastrointestinal tract as well as centrally in the area postrema of the CNS, where the chemoreceptor trigger zone (CTZ) for vomiting is located, resulting in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting and Omeprazole magnesium is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell.
Ondansetron Hydrochloride is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic (It is used to treat nausea and vomiting)
Omeprazole magnesium is a medication used to treat symptoms of indigestion, heartburn, and stomach ulcers. It helps reduce the amount of acids produced in the gastrointestinal tract and actively heals tissues that have already been subjected to acid erosion. Omeprazole magnesium act as a proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux and Zollinger–Ellison syndrome.
It has been demonstrated by recent studies concomitant administration of Ondansetron hydrochloride and omeprazole magnesium shows significantly better symptoms relief compared with the modest improvement of Nausea, Vomiting and Duodenal and gastric ulcer.

Indications and Usage:
●Moderate to severe Nausea, Vomiting
●Duodenal and gastric ulcer
●Laryngopharyngeal reflux.


Ondansetron Hydrochloride:

Pharmacokinetic Actions:
Ondansetron is well absorbed from the gastrointestinal tract and undergoes some first-pass metabolism. Mean bioavailability in healthy subjects, following administration of a single 8-mg tablet, is approximately 56%.
Ondansetron systemic exposure does not increase proportionately to dose. AUC from a 16-mg tablet was 24% greater than predicted from an 8-mg tablet dose. This may reflect some reduction of first-pass metabolism at higher oral doses. Bioavailability is also slightly enhanced by the presence of food but unaffected by antacids. Ondansetron is extensively metabolized in humans, with approximately 5% of a radiolabeled dose recovered as the parent compound from the urine. The primary metabolic pathway is hydroxylation on the indole ring followed by subsequent glucuronide or sulfate conjugation. Although some nonconjugated metabolites have pharmacologic activity, these are not found in plasma at concentrations likely to significantly contribute to the biological activity of Ondansetron.

Omeprazole Magnesium:

Pharmacokinetic Actions:
The absorption of omeprazole takes place in the small intestine and is usually completed within 3–6 hours. The systemic bioavailability of omeprazole after repeated dose is about 60%. Omeprazole bioavailability is significantly impaired by the presence of food and, therefore, patients should be advised to take omeprazole with a glass of water on an empty stomach (i.e., fast for at least 60 minutes before taking omeprazole). Additionally, most sources recommend that after taking omeprazole at least 30 minutes should be allowed to elapse before eating (at least 60 minutes for immediate-release omeprazole plus sodium bicarbonate products, such as Zegerid, though some sources say that with delayed-release forms of omeprazole it is not necessary to wait before eating after taking the medication. Plasma protein binding is about 95%.
Omeprazole is completely metabolized by the cytochrome P450 system, mainly in the liver. Identified metabolites are the sulfone, the sulfide and hydroxy-omeprazole, which exert no significant effect on acid secretion. About 80% of an orally given dose is excreted as metabolites in the urine and the remainder is found in the feces, primarily originating from bile secretion.

Mode of Action:
Both Ondansetron hydrochloride and omeprazole magnesium play very important role and in this combination Ondansetron reduces the activity of the vagus nerve, which activates the vomiting center in the medulla oblongata, and also blocks serotonin receptors in the chemoreceptor trigger zone. It has little effect on vomiting caused by motion sickness and Omeprazole magnesium prevents acid production by blocking enzyme activity in the parietal cells because parietal cells secrete acids that help break down food products. When there is too much acid, serious damage can occur to the lining of the stomach and esophagus. Omeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. By acting specifically on the proton pump, omeprazole blocks the final step in acid production, thus reducing gastric acidity.

● Hypersensitivity to the drug.

Adverse Effects:
Side effects of Ondansetron hydrochloride and omeprazole magnesium are most likely to be minor.

From the above discussion, it can be concluded that this Ondansetron hydrochloride and omeprazole magnesium tablet improve the quality of life with Nausea, Vomiting, Duodenal and gastric ulcer and Laryngopharyngeal reflux. We are making superior quality of Ondansetron hydrochloride and omeprazole magnesium tablet that is used to treat Nausea, Vomiting, Duodenal and gastric ulcer and Laryngopharyngeal reflux. Our offered tablet is processed using high grade chemical compounds and other required drugs by our experienced quality controllers that ensure its quality, purity and chemical properties. Highly treasured among the clients for its reliability, accurate composition, excellent physical and purity, this tablet is offered to our esteemed clients at the market leading prices.