Before knowing its combination, we should need to know that how they work individually, so you know that Etoricoxib is Anti-inflammatory medicines NSAID used to treat rheumatoid, arthritis, Gout and osteoarthritis and Paracetamol is also NSAID and it is used to relieve mild to moderate aches and pains associated with conditions such as headaches, migraine, toothache, teething, colds and flu. It is also useful for reducing fever.
It has been demonstrated by recent studies concomitant administration of Etoricoxib and Paracetamol shows better symptoms relief compared with modest improvement of mild to moderate pain, inflammation and fever.

Indication and Usage:
Combination of Etoricoxib and Paracetamol used to treat:
●Mild to moderate pain for example headaches, muscle aches, arthritis, backache, toothache or the symptoms of a cold.
●Control a fever(high temperature, also known as pyrexia) – for example, when someone has the flu (influenza).
●It is also used for the treatment of Rheumatoid arthritis, Gout and osteoarthritis.

It is readily absorbed from the gastrointestinal tract with peak plasma concentrations occurring about 10 to 60 minutes after oral administration. It is distributed into most body tissues. Plasma protein binding is negligible at usual therapeutic doses but increases with increasing doses. The elimination half-life varies from about 1 to 3 hours.
It is metabolised extensively in the liver and excreted in the urine mainly as inactive glucuronide and sulfate conjugates. Etoricoxib selectively inhibits isoform 2 of cyclo-oxigenase enzyme (COX-2).

Paracetamol is a p-aminophenol derivative that exhibits analgesic and antipyretic activity. It does not possess anti-inflammatory activity. Paracetamol is thought to produce analgesia through a central inhibition of prostaglandin synthesis.

Mode of Action:
Paracetamol works as a painkiller by affecting chemicals in the body called prostaglandins. Prostaglandins are substances released in response to illness or injury. Paracetamol blocks the production of prostaglandins, making the body less aware of the pain or injury. Paracetamol reduces temperature by acting on the area of the brain that is responsible for controlling temperature. Etoricoxib selectively inhibits isoform 2 of cyclo-oxigenase enzyme (COX-2). This reduces prostaglandins (PGs) generation from arachidonic acid.

Drug Interactions:
Usually drug interactions occur when it is taken with another drug or with food. Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications in this combination of etoricoxib and Paracetamol Risk of side effects increased with concomitant use of aspirin, ciclosporin.

Side effects:
Side effects of Etoricoxib and Paracetamol are most likely to be minor like:
●Swelling of your face, lips, tongue

●Caution when used during pregnancy.
●Contraindicated in lactation.
●Caution in active peptic ulceration, and cerebrovascular disease.

From the above discussion, it can be concluded that this Etoricoxib and Paracetamol tablet could improve the quality of life of children with , muscle aches, arthritis, backache, toothache, fever,rheumatoid arthritis, Gout and osteoarthritis.
We are making superior quality of Etoricoxib and Paracetamol tablet that is used to treat Mild to moderate pain and osteoarthritis. Our offered tablets is processed using high grade chemical compounds by our experienced quality controllers that ensure its quality, purity and chemical properties. Highly treasured among the clients for its reliability, accurate composition, excellent physical and purity, this tablet is offered to our esteemed clients at the market leading prices.

Store in cool and dry place.