Febuxostat Tablets

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Therapeutic Indication

Chronic gout
Management of hyperuricemia
Allopurinol intolerance
Alternative therapy when allopurinol fails
Indicated in patients with gout who are intolerant to allopurinol or in whom allopurinol therapy has failed
Prevention of uric acid elevation
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Febuxostat

Tablet

Febuxostat is a xanthine oxidase inhibitor used for treating gout which is caused by excessive levels of uric acid in the blood also known as hyperuricemia. Uric acid is formed from the breakdown of certain chemicals like purines in the body. Febuxostat is a non-hygroscopic, white crystalline powder that is freely soluble in dimethylformamide, dimethylsulfoxide.

Speciality Anti-gout
Tags Xanthine Oxidase Inhibitor
Strength
  • 40 mg
  • 80 mg
Packing Size
  • 10 Tablets

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Mechanism

Febuxostat is a non-purine selective xanthine oxidase inhibitor. It works by inhibiting the enzyme xanthine oxidase, which is responsible for converting hypoxanthine to xanthine and xanthine to uric acid. This leads to a reduction in serum uric acid levels and helps prevent gout attacks.

Pharmacodynamics

Effect On Uric Acid: Febuxostat produces a dose‑dependent reduction in serum uric acid. At daily doses of 40 mg and 80 mg, mean serum uric acid concentrations decrease by approximately 40–55%. This is accompanied by reduced urinary uric acid excretion and increased urinary xanthine excretion.

Side Effects

  • Nausea
  • Joint pain
  • Rash
  • Elevated liver enzymes
  • Gout flare-ups (initial phase)

Contraindication

  • Hypersensitivity to febuxostat
  • Concurrent use with Azathioprine or Mercaptopurine

Interaction

  • Azathioprine (contraindicated)
  • Mercaptopurine (contraindicated)
  • Theophylline
  • Methotrexate
  • Rosuvastatin

Warning and Precautions

  • Increased risk of cardiovascular mortality compared to allopurinol
  • Monitor liver function regularly
  • Use cautiously in patients with cardiovascular disease
  • Not recommended for asymptomatic hyperuricemia

Dosage

As directed by the Physician.

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.