Leflunomide 10 mg Tablet | Uses, Dosage & Benefits

Therapeutic Indication

Rheumatoid Arthritis

Psoriatic Arthritis

Autoimmune Disorders

Inflammatory Joint Diseases

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Leflunomide

Tablet

Leflunomide 10 mg Tablets are an immunomodulatory DMARD indicated for rheumatoid arthritis and psoriatic arthritis. As an isoxazole derivative, Leflunomide is rapidly converted to its active metabolite teriflunomide, which inhibits dihydroorotate dehydrogenase — a key enzyme in pyrimidine synthesis. This selective blockade reduces proliferation of activated lymphocytes, suppresses immune-mediated inflammation, and helps relieve pain, swelling, and joint damage.

Speciality	Anti-rheumatic
Tags	Immunomodulator \| Arthritis
Strength	10 mg 20 mg
Packing Size	10 Tablets

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Mechanism

Inhibits dihydroorotate dehydrogenase enzyme
Blocks pyrimidine synthesis in lymphocytes
Reduces immune cell proliferation and inflammation

Side Effects

Diarrhea
Nausea
Hair loss (alopecia)
Elevated liver enzymes
Hypertension

Contraindication

Pregnancy (teratogenic risk)
Severe liver disease
Hypersensitivity to Leflunomide
Severe immunodeficiency

Interaction

Methotrexate – increased risk of liver toxicity
Warfarin – may alter anticoagulant effect
Rifampicin – increases Leflunomide levels
Live vaccines – reduced immune response

Warning and Precautions

Regular monitoring of liver function tests
Use effective contraception during treatment
Caution in patients with infections
Avoid alcohol consumption

Dosage

As directed by the Physician.

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Leflunomide Tablets